CD95 Unlabeled Antibody

IM1504


The CD95 (Fas or APO-1) antigen is a 40-50 kDa transmembrane glycoprotein. It belongs to the Tumor Necrosis Factor (TNF) superfamily and contains three cysteine-rich repeats. This cell surface molecule mediates apoptosis (programmed cell death). CD95 antigen is expressed on a substantial proportion of peripheral blood CD4+ lymphocytes, CD8+ lymphocytes and B lymphocytes but on a minor proportion of NK cells. It is not found on platelets or erythrocytes, but is expressed variably on granulocytes and monocytes. CD95 is strongly up-regulated on activated T cells, B cells, NK cells and thymocytes. Moreover, it is widely expressed on cell lines of T, B, NK and myeloid lineages. Most other tissues express CD95.

Specifications

Target Species Human
Specificity CD95
Other Names APO-1, CD95, Fas, TNFRSF6
Fluorochrome UNLB
Regulatory Status RUO
Size 0 mg
Format Liquid
Clone CH11
Isotype IgM Mouse
Clone Description The CH11 antibody in vitro induces apoptosis in some CD95 expressing cell lines.

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The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.