DURAClone RE CLB
I pannelli DURAClone RE consentono di rilevare in modo preciso popolazioni di cellule anomale rare nel sangue o nel midollo osseo utilizzando combinazioni di anticorpi attentamente ottimizzati e titolati. Le cellule B periferiche umane mature (linfociti CD45+CD19+) esprimono livelli ad alta densità degli antigeni CD20, CD79b e CD81 sulla loro superficie. Al contrario, gli antigeni CD5, CD43 e ROR1 sono espressi a bassa densità in una piccola frazione di queste cellule. I modelli di espressione che comportano un'alta espressione di CD5, CD43 e ROR1 accompagnata da una ridotta espressione di CD20, CD79b e CD81 possono essere utilizzati per identificare cellule B mature anormali anche a frequenze molto basse.
- Combinazione di 8 marcatori per la rilevazione sensibile di cellule B mature anormali, compresi CD5, CD19, CD20, CD43, CD45, CD79b, CD81, ROR1
- Pannello di anticorpi preformulato in un test unificato a secco che elimina necessità di preparazione miscele di anticorpi
- 25 test per kit, compresi 3 kit di compensazione con coloranti tandem abbinati al lotto
Esclusivamente per utilizzo di ricerca. Non adatto all'utilizzo in procedure diagnostiche.
Features
Expert Panels
- Proven marker combination to detect small populations of normal and abnormal mature B cells
- Open channels to add drop-in markers to modify for different research questions
- Designed for assay precision and lot-to-lot consistency
Efficiency
- Eliminate time spent in titrating different antibody lots
- Avoid waste that comes from preparing cocktail master mix
- Simplify inventory management
Consistency
- Unitized assays eliminate error prone pipetting steps
- Includes lot matched tandem dyes for compensation controls for improved accuracy
- Dry format maintains reagent performance better than liquid under stress conditions
Easy to Use
- Ready to use assay with verified panel design
- Includes sample preparation and staining procedure
- Streamlined workflow, just add sample, incubate, wash and acquire
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